Ligand · 1J5
1J5 · trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexanecarbonitrile
1J5, trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexanecarbonitrile (C17 H19 N5 O, 309.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its…
- Component
- 1J5
- Formula
- C17 H19 N5 O
- Class
- ligand
- Structures
- 4
- PDB entries
- 2
Binding sites
1J5 in 4 structures; the first of them:
- 4IVA · JAK2 kinase (JH1 domain) in complex with the inhibitor… · 1J5 A1201 · binds LEU855, GLY856, LYS857, GLY858, VAL863, ALA880, VAL911, MET929 and 11 more
- 4IVB · JAK1 kinase (JH1 domain) in complex with the inhibitor… · 1J5 A1201 · binds LEU881, GLY882, GLU883, GLY884, VAL889, ALA906, VAL938, MET956 and 11 more
- 4IVA · JAK2 kinase (JH1 domain) in complex with the inhibitor trans-4-[(8AS)… · 1J5 A1201 · binds LEU855, GLY856, LYS857, GLY858, VAL863, ALA880, VAL911, MET929 and 11 more
- 4IVB · JAK1 kinase (JH1 domain) in complex with the inhibitor trans-4-{2… · 1J5 A1201 · binds LEU881, GLY882, GLU883, GLY884, VAL889, ALA906, VAL938, MET956 and 11 more
Residues it binds most
GLY 6, LEU 6, GLU 6, VAL 6, ASP 6, ALA 6, ARG 6, ASN 6, MET 6, SER 6 (residue and the binding sites it lines).
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