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Ligand · 1DT

1DT · N-[(1S)-1-cyclopropylethyl]-2-phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

1DT, N-[(1S)-1-cyclopropylethyl]-2-phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (C18 H18 N4 O2, 322.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å…

Component
1DT
Formula
C18 H18 N4 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

1DT in 2 structures; the first of them:

  • 4I6Q · JAK3 kinase domain in complex with 2-Phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid… · 1DT A1202 · binds LEU828, GLY829, LYS830, VAL836, ALA853, VAL884, MET902, GLU903 and 9 more
  • 4I6Q · JAK3 kinase domain in complex with 2-phenoxy-5H-PYRROLO[2,3- B]PYRAZINE-7-carboxylic acid… · 1DT A1202 · binds LEU828, GLY829, LYS830, VAL836, ALA853, VAL884, MET902, GLU903 and 9 more

Residues it binds most

LEU 2, ALA 2, GLY 2, VAL 2, ARG 2, ASN 2, ASP 2, CYS 2, GLU 2, LYS 2 (residue and the binding sites it lines).

Found with

  • PHU · 1-phenylurea

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