Ligand · 1BU
1BU · 1-{4-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea
1BU, 1-{4-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea (C29 H30 N8 O, 506.6 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its…
- Component
- 1BU
- Formula
- C29 H30 N8 O
- Class
- ligand
- Structures
- 6
- PDB entries
- 3
Binding sites
1BU in 6 structures; the first of them:
- 3F3V · Kinase domain of cSrc in complex with inhibitor RL45 (Type II) · 1BU A1 · binds LEU273, VAL281, ALA293, LYS295, GLU310, VAL313, MET314, LEU317 and 15 more
- 3F3W · Drug resistant cSrc kinase domain in complex with inhibitor RL45 (Type II) · 1BU A1 · binds LEU273, VAL281, ALA293, LYS295, GLU310, VAL313, MET314, LEU317 and 15 more
- 3GCQ · Human P38 MAP kinase in complex with RL45 · 1BU A401 · binds VAL30, VAL38, ALA51, LYS53, ARG67, ARG70, GLU71, LEU74 and 16 more
- 3F3V · Kinase domain of csrc in complex with inhibitor RL45 (type II) · 1BU A1 · binds LEU273, VAL281, ALA293, LYS295, GLU310, VAL313, MET314, LEU317 and 15 more
- 3F3W · Drug resistant csrc kinase domain in complex with inhibitor RL45 (type II) · 1BU A1 · binds LEU273, VAL281, ALA293, LYS295, GLU310, VAL313, MET314, LEU317 and 15 more
- 3GCQ · Human P38 MAP kinase in complex with RL45 · 1BU A401 · binds VAL30, VAL38, ALA51, LYS53, ARG67, ARG70, GLU71, LEU74 and 16 more
Residues it binds most
LEU 10, VAL 10, MET 10, ALA 10, GLU 10, GLY 10, TYR 8, HIS 10, ASP 10, LYS 10 (residue and the binding sites it lines).
Found with
- BOG · octyl beta-D-glucopyranoside
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