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Ligand · 1B2

1B2 · N-{[3-(2H-indazol-5-yl)phenyl]sulfonyl}-L-threoninamide

1B2, N-{[3-(2H-indazol-5-yl)phenyl]sulfonyl}-L-threoninamide (C17 H18 N4 O4 S, 374.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it…

Component
1B2
Formula
C17 H18 N4 O4 S
Class
ligand
Structures
4
PDB entries
2

Binding sites

1B2 in 4 structures; the first of them:

  • 4HWR · Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor · 1B2 A702 · binds TYR313, MET332, CYS334, ARG363, GLU365, MET374, ARG375, VAL376 and 15 more
  • 4HWT · Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor · 1B2 A802 · binds MET444, CYS446, ARG475, GLN493, ASP495, HIS497, TYR573, LYS576 and 11 more
  • 4HWR · Crystal structure of E. COLI threonyl-tRNA synthetase bound to a novel inhibitor · 1B2 A702 · binds TYR313, MET332, CYS334, ARG363, GLU365, MET374, ARG375, VAL376 and 15 more
  • 4HWT · Crystal structure of human threonyl-tRNA synthetase bound to a novel inhibitor · 1B2 A802 · binds MET444, CYS446, ARG475, GLN493, ASP495, HIS497, TYR573, LYS576 and 11 more

Residues it binds most

GLN 8, ARG 8, ALA 8, HIS 8, ASP 8, CYS 8, MET 8, TYR 8, GLY 8, LYS 8 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion

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