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Ligand · 19S

19S · 2-cyclopropyl-N-[(2R)-1-oxo-1-(piperidin-1-yl)propan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

19S, 2-cyclopropyl-N-[(2R)-1-oxo-1-(piperidin-1-yl)propan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (C18 H23 N5 O2, 341.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
19S
Formula
C18 H23 N5 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

19S in 2 structures; the first of them:

  • 4HVI · JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic… · 19S A1201 · binds LEU828, GLY829, LYS830, GLY831, GLY834, SER835, VAL836, ALA853 and 13 more
  • 4HVI · JAK3 kinase domain in complex with 2-cyclopropyl-5H-PYRROLO[2,3- B]PYRAZINE-7-carboxylic… · 19S A1201 · binds LEU828, GLY829, LYS830, GLY831, GLY834, SER835, VAL836, ALA853 and 13 more

Residues it binds most

GLY 2, LEU 2, ALA 2, LYS 2, VAL 2, ARG 2, ASN 2, ASP 2, CYS 2, GLU 2 (residue and the binding sites it lines).

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