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Ligand · 19R

19R · 2-cyclopropyl-N-[(2R)-3-hydroxy-3-methylbutan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

19R, 2-cyclopropyl-N-[(2R)-3-hydroxy-3-methylbutan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (C15 H20 N4 O2, 288.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues…

Component
19R
Formula
C15 H20 N4 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

19R in 2 structures; the first of them:

  • 4HVH · JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic… · 19R A1201 · binds LEU828, GLY829, VAL836, ALA853, VAL884, MET902, GLU903, TYR904 and 8 more
  • 4HVH · JAK3 kinase domain in complex with 2-cyclopropyl-5H-PYRROLO[2,3- B]PYRAZINE-7-carboxylic… · 19R A1201 · binds LEU828, GLY829, VAL836, ALA853, VAL884, MET902, GLU903, TYR904 and 8 more

Residues it binds most

LEU 2, ALA 2, GLY 2, VAL 2, ARG 2, ASN 2, ASP 2, CYS 2, GLU 2, MET 2 (residue and the binding sites it lines).

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