GL1X · GenesisL1 explorer

Ligand · 0T2

0T2 · 2-chloro-3-[(2-cyanopropan-2-yl)oxy]-N-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide

0T2, 2-chloro-3-[(2-cyanopropan-2-yl)oxy]-N-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide (C28 H24 Cl F N6 O3 S, 579.0 g/mol), in the MolNFT structures on GenesisL1: bound in 2…

Component
0T2
Formula
C28 H24 Cl F N6 O3 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

0T2 in 2 structures; the first of them:

  • 4FC0 · Crystal Structure of Human Kinase Domain of B-raf with a DFG-out Inhibitor · 0T2 A901 · binds ILE462, VAL470, ALA480, LYS482, GLU500, VAL503, LEU504, LEU513 and 15 more
  • 4FC0 · Crystal structure of human kinase domain of B-RAF with a dfg-out inhibitor · 0T2 A901 · binds ILE462, VAL470, ALA480, LYS482, GLU500, VAL503, LEU504, LEU513 and 15 more

Residues it binds most

ILE 4, LEU 4, GLU 4, GLY 4, PHE 4, VAL 4, ALA 4, THR 4, ASP 4, CYS 4 (residue and the binding sites it lines).

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.