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Ligand · 0SF

0SF · (2R)-3-{[4-(4-chloro-3-ethylphenoxy)pyrimidin-2-yl][3-(1,1,2,2-tetrafluoroethoxy)benzyl]amino}-1,1,1-trifluoropropan-2-ol

0SF, (2R)-3-{[4-(4-chloro-3-ethylphenoxy)pyrimidin-2-yl][3-(1,1,2,2-tetrafluoroethoxy)benzyl]amino}-1,1,1-trifluoropropan-2-ol (C24 H21 Cl F7 N3 O3, 567.9 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
0SF
Formula
C24 H21 Cl F7 N3 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

0SF in 2 structures; the first of them:

  • 4F2A · Crystal structure of cholestryl esters transfer protein in complex with inhibitors · 0SF A610 · binds ILE11, CYS13, ILE15, LEU129, VAL136, PHE197, VAL198, GLN199 and 13 more
  • 4F2A · Crystal structure of cholestryl esters transfer protein in complex with inhibitors · 0SF A610 · binds ILE11, CYS13, ILE15, LEU129, VAL136, PHE197, VAL198, GLN199 and 13 more

Residues it binds most

ILE 2, LEU 2, PHE 2, VAL 2, ALA 2, ARG 2, CYS 2, GLN 2, HIS 2, PRO 2 (residue and the binding sites it lines).

Found with

  • 2OB · Cholesteryl oleate
  • PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine
  • FUC · alpha-L-fucopyranose
  • MAN · alpha-D-mannopyranose
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • CL · Chloride ion
  • PGE · Triethylene glycol

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