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Ligand · 0RF

0RF · (2S)-2-(4-chlorophenyl)-1-{4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl}-3-(propan-2-ylamino)propan-1-one

0RF, (2S)-2-(4-chlorophenyl)-1-{4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl}-3-(propan-2-ylamino)propan-1-one (C24 H32 Cl N5 O2, 458.0 g/mol), in the MolNFT structures on GenesisL1: bound in 2…

Component
0RF
Formula
C24 H32 Cl N5 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

0RF in 2 structures; the first of them:

  • 4EKL · Akt1 with GDC0068 · 0RF A501 · binds LEU156, GLY157, LYS158, GLY159, GLY162, LYS163, VAL164, ALA177 and 13 more
  • 4EKL · AKT1 with GDC0068 · 0RF A501 · binds LEU156, GLY157, LYS158, GLY159, GLY162, LYS163, VAL164, ALA177 and 13 more

Residues it binds most

GLU 2, GLY 2, LYS 2, ALA 2, LEU 2, MET 2, PHE 2, THR 2, TYR 2, VAL 2 (residue and the binding sites it lines).

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