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Ligand · 0R3

0R3 · {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S,3S)-2-hydroxypentan-3-yl]-3-methyl-2-oxopiperidin-3-yl}acetic acid

0R3, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S,3S)-2-hydroxypentan-3-yl]-3-methyl-2-oxopiperidin-3-yl}acetic acid (C25 H29 Cl2 N O4, 478.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
0R3
Formula
C25 H29 Cl2 N O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

0R3 in 2 structures; the first of them:

  • 4ERF · crystal structure of MDM2 (17-111) in complex with compound 29 (AM-8553) · 0R3 A201 · binds LEU54, LEU57, GLY58, ILE61, MET62, TYR67, PHE86, PHE91 and 6 more
  • 4ERF · Crystal structure of MDM2 (17-111) in complex with compound 29 (am- 8553) · 0R3 A201 · binds LEU54, LEU57, GLY58, ILE61, MET62, TYR67, PHE86, PHE91 and 6 more

Residues it binds most

ILE 6, LEU 6, PHE 6, TYR 6, GLY 6, HIS 6, LYS 6, MET 6, VAL 6, ARG 2 (residue and the binding sites it lines).

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