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Ligand · 0R2

0R2 · [(3R,5R,6S)-1-[(2S)-1-tert-butoxy-1-oxobutan-2-yl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-2-oxopiperidin-3-yl]acetic acid

0R2, [(3R,5R,6S)-1-[(2S)-1-tert-butoxy-1-oxobutan-2-yl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-2-oxopiperidin-3-yl]acetic acid (C27 H31 Cl2 N O5, 520.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
0R2
Formula
C27 H31 Cl2 N O5
Class
ligand
Structures
2
PDB entries
1

Binding sites

0R2 in 2 structures; the first of them:

  • 4ERE · crystal structure of MDM2 (17-111) in complex with compound 23 · 0R2 A201 · binds GLN24, LEU54, PHE55, LEU57, GLY58, GLN59, ILE61, MET62 and 8 more
  • 4ERE · Crystal structure of MDM2 (17-111) in complex with compound 23 · 0R2 A201 · binds GLN24, LEU54, PHE55, LEU57, GLY58, GLN59, ILE61, MET62 and 8 more

Residues it binds most

PHE 4, ILE 4, LEU 4, LYS 4, TYR 4, GLN 2, GLY 4, HIS 4, VAL 4, MET 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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