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Ligand · 0NF

0NF · (2S)-N-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamide

0NF, (2S)-N-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamide (C29 H29 F3 N4 O3, 538.6 g/mol), in the MolNFT structures on GenesisL1…

Component
0NF
Formula
C29 H29 F3 N4 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

0NF in 2 structures; the first of them:

  • 3Q96 · B-Raf kinase domain in complex with a tetrahydronaphthalene inhibitor · 0NF A1 · binds ILE463, VAL471, ALA481, VAL482, LYS483, GLU501, VAL504, LEU505 and 14 more
  • 3Q96 · B-RAF kinase domain in complex with a tetrahydronaphthalene inhibitor · 0NF A1 · binds ILE463, VAL471, ALA481, VAL482, LYS483, GLU501, VAL504, LEU505 and 14 more

Residues it binds most

ILE 4, LEU 4, VAL 4, PHE 4, ALA 4, GLY 4, ASP 4, CYS 4, GLN 4, GLU 4 (residue and the binding sites it lines).

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