GL1X · GenesisL1 explorer

Ligand · 0LG

0LG · N-[(4S,8E,11S)-4-[(1R)-1-hydroxy-2-{[3-(propan-2-yl)benzyl]amino}ethyl]-2,13-dioxo-11-phenyl-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(18),8,14,16-tetraen-16-yl]-N-methylmethanesulfonamide

0LG, N-[(4S,8E,11S)-4-[(1R)-1-hydroxy-2-{[3-(propan-2-yl)benzyl]amino}ethyl]-2,13-dioxo-11-phenyl-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(18),8,14,16-tetraen-16-yl]-N-methylmethanesulfonamide (C35 H44 N4 O6 S, 648.8 g/mol), in the MolNFT…

Component
0LG
Formula
C35 H44 N4 O6 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

0LG in 2 structures; the first of them:

  • 4DPF · BACE-1 in complex with a HEA-macrocyclic type inhibitor · 0LG A500 · binds GLY59, GLN60, LEU78, ASP80, GLY82, SER83, VAL117, PRO118 and 18 more
  • 4DPF · Bace-1 in complex with a hea-macrocyclic type inhibitor · 0LG A500 · binds GLY59, GLN60, LEU78, ASP80, GLY82, SER83, VAL117, PRO118 and 18 more

Residues it binds most

ILE 2, GLY 2, THR 2, ARG 2, ASP 2, GLN 2, SER 2, TYR 2, ASN 2, LEU 2 (residue and the binding sites it lines).

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