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Ligand · 0J8

0J8 · N-(3-nitrobenzyl)-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4-amine

0J8, N-(3-nitrobenzyl)-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4-amine (C23 H21 F3 N8 O2, 498.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
0J8
Formula
C23 H21 F3 N8 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

0J8 in 2 structures; the first of them:

  • 4GG7 · Crystal structure of cMET in complex with novel inhibitor · 0J8 A1401 · binds ILE1084, GLY1085, VAL1092, ALA1108, LEU1140, LEU1157, PRO1158, TYR1159 and 12 more
  • 4GG7 · Crystal structure of cmet in complex with novel inhibitor · 0J8 A1401 · binds ILE1084, GLY1085, VAL1092, ALA1108, LEU1140, LEU1157, PRO1158, TYR1159 and 12 more

Residues it binds most

ALA 2, ASP 2, GLY 2, LEU 2, MET 2, TYR 2, ARG 2, ASN 2, HIS 2, ILE 2 (residue and the binding sites it lines).

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