GL1X · GenesisL1 explorer

Ligand · 0FP

0FP · N-(6-aminohexanoyl)-3-methyl-L-valyl-3-methyl-L-valyl-N~1~-[(2S,3S)-3-hydroxy-4-oxo-4-{[(1R)-1-phenylpropyl]amino}butan-2-yl]-N~4~,N~4~-dimethyl-L-aspartamide

0FP, N-(6-aminohexanoyl)-3-methyl-L-valyl-3-methyl-L-valyl-N~1~-[(2S,3S)-3-hydroxy-4-oxo-4-{[(1R)-1-phenylpropyl]amino}butan-2-yl]-N~4~,N~4~-dimethyl-L-aspartamide (C37 H63 N7 O7, 717.9 g/mol), in the MolNFT structures on GenesisL1: bound…

Component
0FP
Formula
C37 H63 N7 O7
Class
ligand
Structures
6
PDB entries
3

Binding sites

0FP in 6 structures; the first of them:

  • 1JQ7 · HCMV protease dimer-interface mutant, S225Y complexed to Inhibitor BILC 408 · 0FP A261 · binds GLU1031, LEU1032, ASN1062, HIS1063, LEU1131, SER1132, LEU1133, SER1134 and 9 more
  • 1NJU · Complex structure of HCMV Protease and a peptidomimetic inhibitor · 0FP A260 · binds GLU31, LEU32, ASN62, HIS63, LEU131, SER132, LEU133, SER134 and 10 more
  • 1NKM · Complex structure of HCMV Protease and a peptidomimetic inhibitor · 0FP A260 · binds GLU31, LEU32, ASN62, HIS63, LEU131, SER132, LEU133, SER134 and 9 more
  • 1JQ7 · Hcmv protease dimer-interface mutant, S225Y complexed to inhibitor bilc 408 · 0FP A261 · binds GLU1031, LEU1032, ASN1062, HIS1063, LEU1131, SER1132, LEU1133, SER1134 and 9 more
  • 1NJU · Complex structure of hcmv protease and a peptidomimetic inhibitor · 0FP A260 · binds GLU31, LEU32, ASN62, HIS63, LEU131, SER132, LEU133, SER134 and 10 more
  • 1NKM · Complex structure of hcmv protease and a peptidomimetic inhibitor · 0FP A260 · binds GLU31, LEU32, ASN62, HIS63, LEU131, SER132, LEU133, SER134 and 9 more

Residues it binds most

ARG 14, SER 14, LEU 14, HIS 14, CYS 14, ASN 14, GLU 14, GLY 14, ILE 14, VAL 14 (residue and the binding sites it lines).

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