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Ligand · 06M

06M · 6-(but-3-en-1-yl)-4-[6-{1-[(R)-S-methanesulfonimidoyl]cyclopropyl}-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

06M, 6-(but-3-en-1-yl)-4-[6-{1-[(R)-S-methanesulfonimidoyl]cyclopropyl}-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one (C26 H25 N7 O2 S, 499.6 g/mol), in the MolNFT structures on GenesisL1…

Component
06M
Formula
C26 H25 N7 O2 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

06M in 2 structures; the first of them:

  • 7N42 · Crystal structure of the tandem bromodomain of human TAF1 (TAF1-T) bound to ZS1-681 · 06M A1708 · binds TRP1526, PRO1527, PHE1528, HIS1530, PRO1531, VAL1532, ASN1533, PHE1536 and 7 more
  • 7N42 · Crystal structure of the tandem bromodomain of human TAF1 (TAF1-T) bound to ZS1-681 · 06M A1708 · binds TRP1526, PRO1527, PHE1528, HIS1530, PRO1531, VAL1532, ASN1533, PHE1536 and 6 more

Residues it binds most

TYR 2, ASN 2, PHE 2, PRO 2, VAL 2, ASP 2, HIS 2, MET 2, TRP 2 (residue and the binding sites it lines).

Found with

  • DMS · Dimethyl sulfoxide
  • EDO · 1,2-ethanediol

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