GL1X · GenesisL1 explorer

Ligand · 01K

01K · [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate

01K, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate (C31 H53 N10…

Component
01K
Formula
C31 H53 N10 O19 P3 S
Class
ligand
Structures
5
PDB entries
5

Binding sites

01K in 5 structures; the first of them:

  • 3BIY · Crystal structure of p300 histone acetyltransferase domain in complex with a bisubstrate… · 01K A700 · binds ILE1395, SER1396, TYR1397, LEU1398, ASP1399, SER1400, ARG1410, THR1411 and 17 more
  • 4BHW · Structural basis for autoinhibition of the acetyltransferase activity of p300 · 01K A700 · binds SER1396, TYR1397, LEU1398, ASP1399, SER1400, LYS1407, ARG1410, THR1411 and 20 more
  • 6GYR · Transcription factor dimerization activates the p300 acetyltransferase · 01K A1704 · binds SER1396, TYR1397, LEU1398, ASP1399, SER1400, LYS1407, ARG1410, THR1411 and 18 more
  • 8CNA · Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with a… · 01K A1805 · binds ILE1431, SER1432, TYR1433, LEU1434, ASP1435, SER1436, ARG1443, CYS1446 and 20 more
  • 8CND · Crystal structure of CREBBP-Y1482N histone acetyltransferase domain in complex with a… · 01K A1805 · binds ILE1431, SER1432, TYR1433, LEU1434, ASP1435, SER1436, ARG1443, ARG1446 and 19 more

Residues it binds most

TYR 9, PRO 9, ARG 9, LYS 9, ILE 9, SER 9, LEU 9, TRP 9, ASP 9, CYS 9 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • BR · Bromide ion

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